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The cannabinoid hexahydrocannabidiol (H4CBD) is created synthetically, in a similar way as margarine is homogenized. H4CBD is created by adding four hydrogen atoms to the CBD molecule. It's thought to make the CBD experience twofold- more effective because there is a very light euphoric effect, just enough to enhance the CBD experience.
Based on a single study done in 2006, creating homogenized CBD makes it more potent in the brain's CB1 receptor, which is how the euphoric THC binds to the brain's rceptors. Regular CBD binds to the CB2 receptor, found primarily in the body's immune system.
The exact properties of H4CBD remain unknown because of limited research. But, people who use H4CBD generally report that it feels like CBD but with considerably higher psychoactivity.
H4CBD and normal CBD share many properties, but they are not the same molecule. These two cannabinoids have completely different experienced effects, chemical structures and methods of procurement. So, CBD is fundamentally different from H4CBD.
Here are the known differences and similarities between these H4CBD and CBD across seven categories:
Both CBD and H4CBD come from hemp. While CBD is a direct hemp derivative, H4CBD undergoes additional processing, including hydrogenation, for its final form.
As a result, H4CBD is technically a synthetic cannabinoid, although homogenization is similar in simiplicity to margarine. It’s technically possible to synthesize CBD as well, but it's so abundant in hemp, there is no reason to do so.
H4CBD differently in chemical structure, altered to take on a different form from CBD. Four additional hydrogen atoms have been added to the molecule, altering its inherent properties.
Due to the results of a single study from 2006, there’s widespread speculation that H4CBD may be as much as 100 times more potent than CBD — at least in certain ways. The study in question found that hydrogenated forms of CBD showed surprisingly high affinity for the brain’s CB1 neuroreceptors.¹
The level of affinity was nowhere near as high as is observed in the case of THC, but it was nonetheless notable. A 2017 research review echoed this opinion, but no new studies into the bioactive properties of H4CBD had been conducted.²
Anecdotally, H4CBD users have noted that using this cannabinoid feels something like taking a 2:1 CBD:THC product. The familiar, non-intoxicating effects of CBD are still dominant, but there’s also a slight sense of intoxication that might help take the edge off or make the effects of CBD more enjoyable.
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| PACT Act | No |
